Gene Symbol:CXCR2Official Gene Full Name:chemokine (C-X-C motif) receptor 2NCBI Gene Id:3579; 12765; Swissprot Id:P25025, P35343Alias Symbols:CXCR2, IL8RB, C-X-C chemokine receptor type 2, CXC-R2, CXCR-2, CDw128b, GRO/MGSA receptor, High affinity interleukin-8 receptor B, IL-8R B, IL-8 receptor type 2, CD antigen CD182Description of Target:The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified.Molecular Weight:48 kDaHost:RabbitClonality:PolyclonalPurification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Application:WB, IHC, IF, ELISATissue Tool:Find tissues and cell lines supported by DNA array analysis to express CXCR2. 
RNA Seq:Find tissues and cell lines supported by RNA-seq analysis to express CXCR2. 
Immunogen:Synthesized peptide derived from human IL-8RBeta around the phosphorylation site of S347. Location: 290-370aa.Predicted Species Reactivity:Human, MouseProduct Format:Liquid. 1 mg/mL in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Reconstitution and Storage:Store at -20C. Avoid repeated freeze/thaw cycles.Concentration:1 mg/mlDatasheets/Manuals:Printable datasheet for anti-CXCR2 (OASG03857) antibodyTarget Post-Translational Modification:Phospho-Ser347Specificity:Phospho-IL-8RBeta (S347) Polyclonal Antibody detects endogenous levels of IL-8RBeta protein only when phosphorylated at S347.Isotype:IgG
