| Predicted Species Reactivity | Mouse |
|---|---|
| Product Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Clonality | Polyclonal |
| Host | Rabbit |
| Application | WB |
| Reconstitution and Storage | For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Immunogen | The immunogen is a synthetic peptide directed towards the middle region of mouse SIRT7 |
| Purification | Affinity purified |
| Peptide Sequence | Synthetic peptide located within the following region: RQVSRILRKAAAERSAEEGRLLAESEDLVTELQGRSRRREGLKRRQEEVC |
| Concentration | Batch dependent within range: 100 ul at 0.5 - 1 mg/ml |
| Blocking Peptide | For anti-SIRT7 (ARP89637_P050) antibody is Catalog # AAP89637 |
| Datasheets/Manuals | Printable datasheet for anti-SIRT7 (ARP89637_P050) antibody |
| Gene Symbol | SIRT7 |
|---|---|
| Official Gene Full Name | sirtuin 7 |
| NCBI Gene Id | 209011 |
| Protein Name | NAD-dependent protein deacetylase sirtuin-7 |
| Description of Target | NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at "Lys-18" (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions (By similarity). Required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis. Promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation. |
| Swissprot Id | Q8BKJ9 |
| Protein Accession # | NP_694696.2 |
| Nucleotide Accession # | NM_153056.2 |
| Protein Size (# AA) | 402 |
| Molecular Weight | 45 kDa |
| Tissue Tool | Find tissues and cell lines supported by DNA array analysis to express SIRT7.  |
| RNA Seq | Find tissues and cell lines supported by RNA-seq analysis to express SIRT7.  |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
- IHC Tips & Tricks
- ICC Tips & Tricks
- ELISA Tips & Tricks
- WB/IB Tips & Tricks
- IP Tips & Tricks
See our General FAQ page.
What is the species homology for "SIRT7 Antibody - middlel region (ARP89637_P050)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Mouse".
How long will it take to receive "SIRT7 Antibody - middlel region (ARP89637_P050)"?
This item is available "Domestic: within 24 hours delivery | International: 3-5 days".
What buffer format is "SIRT7 Antibody - middlel region (ARP89637_P050)" provided in?
This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".Additional format options may be available. For more information please contact info@avivasysbio.com.
What are other names for "SIRT7 Antibody - middlel region (ARP89637_P050)"?
This target may also be called "" in publications.
What is the shipping cost for "SIRT7 Antibody - middlel region (ARP89637_P050)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
What is the guarantee for "SIRT7 Antibody - middlel region (ARP89637_P050)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
Can I get bulk pricing for "SIRT7 Antibody - middlel region (ARP89637_P050)"?
You can get bulk pricing for this item by going here.
What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "45 kDa".Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.
What protocols are available for "SIRT7 Antibody - middlel region (ARP89637_P050)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
What are positive controls for "SIRT7"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
What are negative controls for "SIRT7"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
What other proteins interact with "SIRT7"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
What biological processes are associated with "SIRT7"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
What cellular components are associated with "SIRT7"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
What protein functions are associated with "SIRT7"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.
